Harmful or Physiologic

Nesiritide: harmful or harmless?

Nesiritide is the recombinant form of human B-type (brain) natriuretic peptide (BNP), and its amino acid sequence is identical to that of endogenous human BNP. Administration of nesiritide results in venous and arterial vasodilation, as well as enhanced diuresis. Given the many limitations of therapies previously available for the treatment of acute decompensated heart failure, the anticipation...

variable ventilation stochastic or physiologic

variability of tidal volume and respiratory rate in normally breathing man has long been demonstrated [1]. however because of lack of knowledge and technology primary ventilators could only deliver a fixed tidal volume in a fixed rate the so called volume controlled ventilation (vcv). vcv was volume preset time triggered and cycled and there was no synchronization with patient’s breaths. at tha...

IMSI, Useful, Useless or Harmful?

Since the birth of the first test-tube baby in 1978, Assisted Reproduction Techniques (ART) has been performed all over the world to alleviate human infertility. In 1991 with the advent of the Intra-Cytoplasmic Sperm Injection (ICSI) technique, a reasonable rate of male infertility cases due to severe oligospermia were successfully solved. However, several concerns about the safety and impact o...

Cancer Screening, Effective or Harmful?

Once a widely accepted notion, mammography screening is now called into doubt, in some cases rendered unjustifiable, by studies in developed countries. In spite of the fact that screening cannot prove to be effective may seem meaningless at the first glance, in practice, the procedures and strategies are to be reconstructed. In Iran, for instance, 40% of diagnosed breast cancer in women are loc...

neuraxial dexmedetomidine: wonder drug or simply harmful